![]() All of the bones of the body, except for the flat bones of the skull, mandible, and clavicles, are formed through endochondral ossification. Endochondral OssificationĮndochondral ossification is the process of bone development from hyaline cartilage. The spongy bone is remodeled into a thin layer of compact bone on the surface of the spongy bone. Connective tissue in the matrix differentiates into red bone marrow in the fetus. The non-mineralized portion of the bone or osteoid continues to form around blood vessels, forming spongy bone. Osteoblasts secrete the extracellular matrix and deposit calcium, which hardens the matrix. They then differentiate into osteoblasts at the ossification center. ![]() Ossification begins as mesenchymal cells form a template of the future bone. It is involved in the formation of the flat bones of the skull, the mandible, and the clavicles. Intramembranous ossification is the process of bone development from fibrous membranes. Bones can grow in thickness throughout life, but after age 25, ossification functions primarily in bone remodeling and repair. Bone growth continues until approximately age 25. The development of bone from fibrous membranes is called intramembranous ossification development from hyaline cartilage is called endochondral ossification. Before this time, the embryonic skeleton consists entirely of fibrous membranes and hyaline cartilage. Ossification begins approximately six weeks after fertilization in an embryo. ![]() Ossification is distinct from the process of calcification whereas calcification takes place during the ossification of bones, it can also occur in other tissues. ![]() Ossification, or osteogenesis, is the process of bone formation by osteoblasts. Describe how bones develop, grow, and repair. ![]()
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